David A Largaespada Selected Research

Hepatocellular Carcinoma (Hepatoma)

5/2023	DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo.
1/2019	Evaluating the landscape of gene cooperativity with receptor tyrosine kinases in liver tumorigenesis using transposon-mediated mutagenesis.
9/2013	Retrotransposons: a new and credible source of inherited and somatically acquired hepatocellular carcinoma mutations.
3/2009	A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.

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David A Largaespada Research Topics

Disease

67	Neoplasms (Cancer) 06/2024 - 07/2003
15	Neurofibrosarcoma (MPNST) 06/2024 - 07/2013
10	Carcinogenesis 01/2020 - 03/2009
9	Neurofibroma 10/2023 - 07/2012
8	Leukemia 11/2022 - 04/2002
8	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2020 - 05/2006
7	Neurofibromatosis 1 (Neurofibromatosis Type I) 09/2023 - 02/2007
7	Osteosarcoma (Osteogenic Sarcoma) 12/2020 - 06/2015
6	Plexiform Neurofibroma 03/2024 - 03/2014
6	Medulloblastoma 01/2023 - 02/2012
6	Neoplasm Metastasis (Metastasis) 10/2022 - 12/2016
6	Glioblastoma (Glioblastoma Multiforme) 01/2020 - 08/2004
5	Brain Neoplasms (Brain Tumor) 01/2022 - 01/2009
5	Glioma (Gliomas) 01/2021 - 11/2005
4	Hepatocellular Carcinoma (Hepatoma) 05/2023 - 03/2009
4	Sarcoma (Soft Tissue Sarcoma) 01/2021 - 01/2007
4	Myeloid Leukemia (Leukemia, Myelocytic) 10/2016 - 04/2002
3	Nerve Sheath Neoplasms (Nerve Sheath Neoplasm) 10/2023 - 01/2012
3	Inflammation (Inflammations) 08/2021 - 01/2019
3	Neurofibromatoses (Neurofibromatosis) 01/2021 - 07/2013
2	Breast Neoplasms (Breast Cancer) 10/2022 - 09/2015
2	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 03/2009
2	Adenocarcinoma 01/2021 - 04/2012
2	Liver Neoplasms (Liver Cancer) 01/2019 - 05/2012
2	Carcinoma (Carcinomatosis) 11/2017 - 11/2005
2	Lymphoma (Lymphomas) 11/2009 - 04/2002
2	Prostatic Neoplasms (Prostate Cancer) 05/2009 - 01/2007
1	Hematologic Neoplasms (Hematological Malignancy) 04/2024
1	Hypoxia (Hypoxemia) 11/2023
1	Bites and Stings (Sting) 11/2023
1	Rupture 01/2023
1	Hypertrophy 04/2021
1	Animal Disease Models 02/2021

Drug/Important Bio-Agent (IBA)

17	Proteins (Proteins, Gene)FDA Link 09/2023 - 04/2005
11	RNA (Ribonucleic Acid)IBA 10/2022 - 05/2010
10	DNA (Deoxyribonucleic Acid)IBA 11/2023 - 04/2005
6	Small Interfering RNA (siRNA)IBA 01/2021 - 03/2011
6	TransposasesIBA 02/2015 - 08/2004
5	CateninsIBA 03/2021 - 03/2011
4	Neurofibromin 1 (Neurofibromin)IBA 09/2023 - 02/2007
4	AntigensIBA 01/2022 - 10/2013
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021 - 11/2014
4	ErbB Receptors (EGF Receptor)IBA 07/2014 - 01/2012
3	LigandsIBA 01/2021 - 06/2013
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2021 - 05/2010
3	Phosphotransferases (Kinase)IBA 01/2021 - 09/2015
3	GTPase-Activating Proteins (GTPase-Activating Protein)IBA 12/2016 - 07/2003
3	Cytarabine (Cytosar-U)FDA LinkGeneric 11/2016 - 05/2006
3	Transcription Factors (Transcription Factor)IBA 07/2016 - 05/2012
3	MutagensIBA 08/2015 - 01/2007
2	Chimeric Antigen ReceptorsIBA 04/2024 - 01/2016
2	Inhibitor of Apoptosis ProteinsIBA 11/2023 - 02/2023
2	Folic Acid (Vitamin M)FDA LinkGeneric 10/2023 - 01/2013
2	CytosineIBA 05/2023 - 12/2020
2	Antiviral Agents (Antivirals)IBA 05/2023 - 12/2020
2	Doxorubicin (Adriamycin)FDA LinkGeneric 08/2021 - 11/2017
2	Oncogene Proteins (Oncogene Protein)IBA 01/2021 - 11/2014
2	Calcibiotic Root Canal SealerIBA 01/2021 - 03/2009
2	AZD 6244IBA 01/2021 - 01/2021
2	Complementary DNA (cDNA)IBA 01/2020 - 04/2005
2	VaccinesIBA 01/2020 - 10/2013
2	Mitogen-Activated Protein KinasesIBA 01/2020 - 11/2005
2	Guanosine Triphosphate (GTP)IBA 01/2019 - 08/2007
2	CytokinesIBA 10/2016 - 09/2014
2	Transcription Activator-Like Effector NucleasesIBA 01/2016 - 08/2014
2	DNA Transposable Elements (Element, IS)IBA 08/2015 - 01/2007
2	parthenolideIBA 08/2015 - 06/2015
2	Retroelements (Retrotransposon)IBA 09/2013 - 04/2013
2	ElementsIBA 04/2013 - 08/2007
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 07/2012 - 01/2012
2	TensinsIBA 07/2012 - 01/2012
2	Trans-Activators (Trans-Acting Factor)IBA 01/2009 - 08/2007
2	Tetracycline (Achromycin)FDA LinkGeneric 01/2009 - 08/2007
2	LuciferasesIBA 11/2005 - 08/2004
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 06/2024
1	Indicators and Reagents (Reagents)IBA 04/2024
1	Synthetic DrugsIBA 03/2024
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2023
1	InterferonsIBA 11/2023
1	Nonsense Codon (Nonsense Mutation)IBA 09/2023
1	Single-Stranded DNA (DNA, Single Stranded)IBA 05/2023
1	A-Form DNA (A-DNA)IBA 05/2023
1	EnzymesIBA 05/2023
1	Glutamic Acid (Glutamate)FDA Link 05/2023
1	Unithiol (DMPS)IBA 01/2023
1	Immobilized Nucleic AcidsIBA 01/2023
1	G-Protein-Coupled Receptor KinasesIBA 10/2022
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 10/2022
1	muskIBA 10/2022
1	Single-Chain AntibodiesIBA 01/2022
1	Immune Checkpoint ProteinsIBA 01/2022
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2022

Therapy/Procedure

36	Therapeutics 06/2024 - 08/2004
4	Drug Therapy (Chemotherapy) 01/2020 - 05/2006
3	Immunotherapy 01/2021 - 09/2013
3	Transplantation 11/2020 - 03/2016
1	Injections 06/2024
1	Radiotherapy 11/2023
1	Intraperitoneal Injections 01/2022
1	Precision Medicine 01/2021